Senior Investigator, and Staff Anatomic Pathology
Center for Cancer Research, NCI, NIH
Frederick, Maryland, United States
Dr. Mackem received her PhD from the Univ. of Chicago as an MSTP trainee, for identifying VP16-responsive HSV IE-enhancers, her MD from Johns Hopkins Univ. School of Medicine, and residency training in Anatomic Pathology at the National Cancer Institute, after which she joined the Laboratory of Pathology, NCI as a staff member and then the Cancer and Developmental Biology Laboratory at NCI-Frederick as Senior Investigator in 2009. She also serves as an attending anatomic pathologist for the NIH Clinical Center.
Dr. Mackem studies limb development as a model for learning how signaling networks orchestrate the formation of a complex 3-dimensional structure, using combined genetic, genomic, and biochemical approaches to elucidate transcription factors and signaling cascades that regulate the formation and pattern of digits and uncover the regulatory hierarchy between early patterning and digit morphogenesis. A major focus of the lab has been the role of Sonic Hedgehog and its signaling targets, including the Gli3 hedgehog-effector and 5’Hoxd homeobox gene targets that cooperate to regulate the late morphogenetic realization of early patterning cues triggered by Shh.
Limb Development, Evolution, and Regeneration
Saturday, March 25, 2023
10:30 AM – 12:00 PM US EST
Regulation of Pattern Formation During Embryonic Development
Saturday, March 25, 2023
10:30 AM – 11:00 AM US EST
